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  • Conserved economics of transcription termination in ...

    Interestingly, the strongest terminators downstream of each gene (compare 'Best' with 'All' in Fig. 5A and C) show a more dramatic peak. Thus, the strongest structures are usually encountered first after the stop codon by the RNA polymerase and are probably responsible for most transcription termination.

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  • Biomolecular Matchmaking Material Misfits Solar Power's ...

    highest peak. It is a collaboration among more than 100 scientists at 30 institutions, including its operations manager at Los Alamos National Laboratory. Unlike most other gamma- and cosmic-ray observatories, HAWC continuously scans a large fraction of .

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  • Proteomic profiling of glucocorticoid ... - Proteome Science

    Results showed an increase in RPS13 levels detectable through T15 (15 minutes) post-exposure. Quantitation was performed on the intercalating zoom scans for the corresponding MS2 scan by taking the ratio of the monoisotopic peak of the heavy (labeled) peak divided by the monoisotopic peak of the light (unlabeled, prednisone-exposed) peak.

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  • Attenuation | definition of attenuation by Medical dictionary

    attenuation [ah-ten″u-a´shun] 1. the act of thinning or weakening. 2. the change in the virulence of a pathogenic microorganism induced by passage through another host species, decreasing its virulence for the native host and increasing it for the new host. This is the basis for the development of live vaccines. 3. the change in a beam of radiation ...

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  • Evaluation of [11C]NMS-E973 as a PET tracer for in vivo ...

    The client proteins processed by the HSP90 machinery are abundant; over 400 have been reported, encompassing kinases, transcription factors, E3-ubiquitin ligases, steroid hormone receptors and other essential signalling proteins [7,8]. Many of these client proteins contribute to the six hallmarks of cancer .

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  • Heritability of autism - Wikipedia

    The heritability of autism is the proportion of differences in expression of autism that can be explained by genetic variation; if the heritability of a condition is high, then the condition is considered to be primarily genetic. Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether autism spectrum disorder (ASD) is explained more by multigene ...

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  • Molecules | Free Full-Text | Structural Basis for the ...

    Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its target gene transcription. In this study, we characterized the molecular interaction between p53 transactivation domain (p53TAD) and activator ...

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  • Paired-End Analysis of Transcription Start Sites in ...

    7/1/2014· Understanding plant gene promoter architecture has long been a challenge due to the lack of relevant large-scale data sets and analysis methods. Here, we present a publicly available, large-scale transcription start site ([TSS][1]) data set in plants using a high-resolution method for analysis of 5′ ends of mRNA transcripts. Our data set is produced using the paired-end analysis of ...

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  • Identification of Essential Subunits in the Plastid ...

    The major RNA polymerase activity in mature chloroplasts is a multisubunit, Escherichia coli -like protein complex called PEP (for plastid-encoded RNA polymerase). Its subunit structure has been extensively investigated by biochemical means. Beside the "prokaryotic" subunits encoded by the plastome-located RNA polymerase genes, a number of additional nucleus-encoded subunits of eukaryotic ...

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  • Ring1-mediated ubiquitination of H2A restrains poised RNA ...

    11/25/2007· Interestingly, HDAC1 and p300, two other components of the transcription machinery, also bound at the silent Nkx2.2 locus in ES cells, with a prominent peak in .

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  • Genome-wide analysis of G-quadruplexes in herpesvirus ...

    11/21/2016· G-quadruplexes are increasingly recognized as regulatory elements in human, animal, bacterial and plant genomes. The presence and function of G-quadruplexes are not well studied among herpesviruses; in particular, there are no systematic genome-wide analysis of these important secondary structures in herpesvirus genomes. We performed genome-wide analysis of putative quadruplex .

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  • Profile | College of Medicine and Health | University of ...

    Professor Clive Ballard Pro-Vice Chancellor and Executive Dean 2911 722911 Medical School Building F.04 . Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

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  • Calcium Imaging of Parvalbumin Neurons in the Dorsal Root ...

    We investigated the calcium dynamics of dorsal root ganglion (DRG) neurons using transgenic mice to target expression of the genetically encoded calcium indicator (GECI), GCaMP6s, to a subset of neurons containing parvalbumin (PV), a calcium-binding protein present in proprioceptors and low-threshold mechanoreceptors. This study provides the first analysis of GECI calcium transient parameters ...

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  • DNA specificities modulate the binding of human ...

    TFAM/Site-Y complex (351.5 μM TFAM concentration; 9 mg/ml) yielded two peaks of 62 ± 2 and 47 ± 1 kDa. Similar to LSP, the first peak corresponds to a 2:1 stoichiometry. However, the second peak could be a mixture of the 2:1 and 1:1 complexes, because of less efficient separation of these species.

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  • Cell cycle-regulated histone acetylation required for ...

    This peak of acetylation precedes HO transcription by ∼15–30 min (Fig.A) and declines with kinetics similar to the disappearance ofHO transcripts (Fig. A). Furthermore, G 1 acetylation of the HO locus is absent in gcn5 ash1cells (open bars), and it does not occur at the rDNA locus (right) or throughout the yeast genome (center).

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  • Transcriptional Control in the Segmentation Gene Network ...

    The segmentation gene network of Drosophila consists of maternal and zygotic factors that generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity along the anterior-posterior axis of the embryo. Using known binding site information for maternal and zygotic gap ...

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  • Linear mitochondrial DNA is rapidly degraded by components ...

    4/30/2018· Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing ...

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  • Linear mitochondrial DNA is rapidly degraded by components ...

    4/30/2018· Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing ...

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  • Translational Control of Viral Gene Expression in ...

    As obligate intracellular parasites, viruses rely exclusively on the translational machinery of the host cell for the synthesis of viral proteins. This relationship has imposed numerous challenges on both the infecting virus and the host cell. Importantly, viruses must compete with the endogenous transcripts of the host cell for the translation of viral mRNA.

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  • Vol. 33, No. 11 | The FASEB Journal

    If the address matches an existing account you will receive an email with instructions to reset your password

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